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Close monitoring of the blood pressure is required during therapy. CARDENE I.V. is contraindicated in patients with
known hypersensitivity to the drug and in patients with advanced aortic stenosis. Reduction of diastolic
pressure and reduced afterload may worsen rather than improve myocardial oxygen balance. Caution is advised when
administering CARDENE I.V. to patients with impaired renal or hepatic function, in combination with a
beta-blocker in patients with congestive heart failure, or portal hypertension. Observe caution in patients with
significant left ventricular dysfunction due to possible negative inotropic effect. CARDENE I.V. gives no
protection against the dangers of abrupt beta-blocker withdrawal; beta-blocker dosage should be gradually reduced.
Levels of cyclosporine should be closely monitored during therapy. The most common side effects of CARDENE I.V.
are headache (14.6%), hypotension (5.6%), nausea/vomiting (4.9%), and tachycardia (3.5%). Less frequent adverse
effects, in each case occurring at 1.4%, include ECG abnormalities, postural hypotension, ventricular extrasystoles,
injection-site reaction, dizziness, sweating and polyuria.
Please see full prescribing information.
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